Copyright
©The Author(s) 2015.
World J Gastroenterol. Nov 14, 2015; 21(42): 11984-12002
Published online Nov 14, 2015. doi: 10.3748/wjg.v21.i42.11984
Published online Nov 14, 2015. doi: 10.3748/wjg.v21.i42.11984
Type of vaccine | Lead author | Year | Vaccine | Tested in | Adjuvant | Ref. |
Recombinant protein | Leroux-Roels | 2004 | Recombinant E1 (T2S-918/InnoVac-C) | Human n = 20 | Alum | [160] |
Choo | 1994 | Recombinant E1 or E2 | Chimpanzee n = 7 | MF59 | [153] | |
Frey | 2010 | Recombinant E1 or E2 | Human n = 60 | MF59 | [161] | |
Drane | 2009 | Recombinant Core | Human n = 30 | ISCOMATRIX | [163] | |
Verstrepen | 2011 | Recombinant E1 or E2 | Chimpanzee n = 4 | Alum | [162] | |
Puig | 2004 | Recombinant E1 or E2 | Chimpanzee n = 2 | Oil/water | [155] | |
Peptide | Firbas | 2006 | 7 HLA-A2 restricted peptides (IC41) | Human n = 128 | Poly-L-arginine | [149] |
Firbas | 2010 | 7 HLA-A2 restricted peptides (IC41) | Human n = 54 | Poly-L-arginine | [150] | |
Yutani | 2007 | Peptide vaccine targeting E1, E2, NS3 and NS5A | Human n = 12 | - | [145] | |
Klade | 2008 | Synthetic peptide vaccine (core, NS3, NS4) (IC41) | Human n = 60 | Poly-L-arginine | [146] | |
DNA vaccine | Forns | 2000 | DNA vaccine expressing E2 protein | Chimpanzee n = 2 | - | [227] |
Sallberg | 2009 | NS3/4A expressing plasmid (ChronVac-C) | Human n = 12 | - | [179] | |
Alvarez-Lajonchere | 2009 | Plasmid (CIGB-230) expressing core, E1, E2 plus recombinant core protein | Human n = 15 | - | [175] | |
Virally vectored | Rollier | 2007 | DNA/MVA | Chimpanzee n = 4 | - | [201] |
Folgori | 2006 | Ad6/Ad24 + electroporated DNA | Chimpanzee n = 5 | - | [191] | |
Fattori | 2006 | Ad6/Ad6/ChAd32 | Rhesus macaque n = 3 | - | [194] | |
Barnes | 2012 | Ad6/ChAd3 | Human n = 30 | - | [193] | |
Youn | 2008 | Recombinant vaccinia | Chimpanzee n = 4 | - | [207] | |
Habersetzer | 2009 | Modified vaccinia Ankara virus expressing HCV NS3-NS5B (TG4040) | Human n = 15 | - | [203] | |
Others | Elmowalid | 2007 | Virus like particles | Chimpanzee n = 4 | AS01B | [215] |
Batdelgar | 2008 | V-5 Immunitor–heat- inactivated HCV antigens from HCV infected donors (tablet administered orally) | Human n = 10 | - | [219] |
- Citation: Ghasemi F, Rostami S, Meshkat Z. Progress in the development of vaccines for hepatitis C virus infection. World J Gastroenterol 2015; 21(42): 11984-12002
- URL: https://www.wjgnet.com/1007-9327/full/v21/i42/11984.htm
- DOI: https://dx.doi.org/10.3748/wjg.v21.i42.11984