Non-coding landscapes of colorectal cancer

Table 1 Functions of microRNAs deregulated in colorectal cancer

microRNA	Oncogene/tumor suppressor	Process in CRC	Targets	PMID
Let-7	Tumor suppressor	Cell proliferation, migration, invasion, metastasis	KRAS, MMP11, PBX3	23167843, 21984339, 16651716
miR-1	Tumor suppressor	Cell proliferation, invasion, migration	MET	22179665
miR-16	Tumor suppressor	Cell proliferation	PTGS2	22049153
miR-17-92 cluster	Oncogene	Angiogenesis, proliferation, metastasis	TSP-1, CTGF, PTEN, BCL2L11, E2F1, E2F2, E2F3, TGFBR2, CDKN1A, BIM	19460962, 16878133, 22308110, 24212931, 21883694
miR-18a	Tumor suppressor	Cell proliferation, migration	CDC42, HNRNPA1	25379703, 24166503
miR-21	Oncogene	Cell proliferation, migration, invasion, metastasis, stemness	PDCD4, CCL20, Cdc25A, TGFBR2, PTEN, RHOB, RASA1	22677902, 17968323, 22099878, 19826040, 22120473, 23788041, 23544170, 23174819, 22072622, 21872591, 25663768
miR-23b	Tumor suppressor	Cell migration, invasion, angiogenesis	FZD7, MEKK1, PAK2, TGFBR2, RRAS2, PLAU, VEGF	22109528
miR-31	Oncogene	Cell proliferation, invasion, migration	CDKN2B, RASA1	21062447, 25202407, 23322774
miR-34	Tumor suppressor	Migration, invasion, metastasis, EMT	IL6R, ZNF281, MET, SNAIL, CTNNB1, SLUG, ZEB1	24642471, 24185900, 23243217, 22134354
miR-101	Tumor suppressor	Cell proliferation, motility, invasion	EP4, PTGS2	22353936, 19133256
miR-103/miR-107	Oncogene	Invasion, migration, metastasis	DAPK, KLF4	22593189
miR-106a	Oncogene	Cell proliferation, migration, invasion, metastasis	RB1, TGFBR2	23178825, 22912877
miR-126	Tumor suppressor	Cell proliferation, migration, invasion, metastasis, angiogenesis	PIK3R2, IRS1, CXCR4, VEGF	18663744, 24312276, 24189753, 24653631, 23900443
miR-135a	Oncogene	Cell proliferation, migration, invasion	MTSS1	23017832
miR-135b	Oncogene	Cell proliferation, invasion	APC, TGFBR2, DAPK1	18632633, 24735923
miR-143	Tumor suppressor	Cell proliferation, metastasis	KRAS, ERK5, MACC1, HK2, IGF1R, DNMT3A	19137007, 16969504, 22533346, 22691140, 23574723, 19638978
miR-145	Tumor suppressor	Cell proliferation, angiogenesis	MYC, CDK6, E2F1, CCND2, p70S6K1, PAK4	21278451, 15944709, 19843336, 21917858, 22766504
miR-148a	Tumor suppressor	Cell proliferation	BCL2	21455217
miR-155	Oncogene	Cell proliferation, migration, invasion, chemoresistance	CLDN1	23588589, 23036199
miR-181a	Oncogene	Cell proliferation, invasion, metastasis, EMT	PTEN, WIF1	24685694, 24755295
miR-200c	Tumor suppressor	Cell proliferation, invasion, migration, EMT, metastasis	ZEB1, ETS1, FLT1, CDH1, VIM	22735571, 22407310
miR-210	Oncogene	Cell migration, invasion	VMP1	24632577
miR-320a	Tumor suppressor	Cell proliferation, migration, invasion, metastasis, EMT	CTNNB1, RAC1, NRP1	22459450, 24265291, 22134529
miR-372	Oncogene	Cell proliferation	TXNIP, LATS2	22660396, 22456107
miR-638	Tumor suppressor	Cell invasion, migration	SOX2, TSPAN1	24885288, 25301729
miR-720	Oncogene	Cell proliferation, invasion, migration	STARD13	25286763, 22660396

For all miRNAs are reported: (1) their function in CRC (oncogene, or tumor suppressor); (2) the biological processes they are involved in; (3) their mRNA validated targets; (4) bibliographic references reported as PubMed ID (PMID).