Genetic, metabolic and environmental factors involved in the development of liver cirrhosis in Mexico

Table 3 Genetic polymorphisms associated with the outcomes of hepatitis B virus infection

Gene	Risk allele	Association	Population	Ref.
Immune response mediators
IL-10	-592 C	Significant increased risk of LC	Asian	[139]
IL-28B	rs12979860 C	Increased risk for developing LC	Asian	[140]
TGF-β1	10 T	Higher prevalence of LC	Chinese	[141]
TGF-β1	-509 C	Higher susceptibility to LC	Chinese	[142]
Fibrogenesis
COL1A1	TC haplotype (-1997 T, -1363 C)	Higher prevalence of LC	Chinese	[143]
COL3A1	rs3106796 A	Higher prevalence of chronic hepatitis, LC and HCC	Koreans	[144]

LC: Liver cirrhosis; HCC: Hepatocellular carcinoma.