Signet-ring cell carcinoma of the stomach: Impact on prognosis and specific therapeutic challenge

Table 2 Studies assessing prognosis of the signet-ring cell histotype in early gastric cancers

Ref.	Number of patients in study	Number of early gastric cancers	SRCC frequency in early gastric cancer	Prognosis of SRCC (type of analysis)
Maehara et al[57] (1992)	1500	384	7.3%	Similar (univariate)
Otsuji et al[58] (1998)	1498	568	19.8%	Better (univariate)
Hyung et al[80] (2002)	3104	933	28.2%	Better (univariate)
Kim et al[45] (2004)	2358	561	16.7%	Similar (multivariate)
Kunisaki et al[43] (2004)	1113	513	23.4%	Better (multivariate)
Ha et al[42] (2008)	1520	1520	25.5%	Better (univariate)
Jiang et al[44] (2011)	2315	269	20.1%	Better (multivariate)
Kwon et al[11] (2014)	769	326	15.6%	Better (multivariate)
Gronnier et al[46] (2013)	421	421	25%	Similar (multivariate)

SRCC: Signet-ring cell carcinoma.