Signet-ring cell carcinoma of the stomach: Impact on prognosis and specific therapeutic challenge

Table 1 Clinical hereditary diffuse gastric cancer testing criteria (from van der Post J Med Genet 2015[18])

Criteria include first and second degree relatives
Established criteria	2 GC cases regardless of age, at least one confirmed DGC
	One case of DGC < 40
	Personal or family history of DGC and LBC, one diagnosed < 50
Families in whom testing could be considered	Bilateral LBC or family history of 2 or more cases of LBC < 50
	Personal or familial history of cleftlip/palate in a patient with DGC
	In situ signet ring cell and/or pagetoid spread of signet ring cells

GC: Gastric cancer; DGC: Diffuse gastric cancer; LBC: Lobular breast cancer.