Tight junction disruption: Helicobacter pylori and dysregulation of the gastric mucosal barrier

Table 2 Characteristics of human gastric cell lines that are used to study the role of Helicobacter pylori in tight junction dysfunction during infection

Cultured cell line	ZO-1, 2, or 3	Occludin	JAM’s	Tricellulin	Cldns	Confluency	Ref.	Cldns not expressed
AGS	ZO-1				2, 4, 6, 7, 9	Confluent monolayer with no TER	[82,92,123-126]	11[119]
BGC-823			JAM-A (low)		1, 18		[19,38,71]
GES-1			JAM-A (high)				[19]
HFE-145					11		[119]
HGE-20	ZO-1				4	Confluent monolayer with TER-polarized	[65,80,81]
HS-746T					1		[71]
HSC-39					2		[111]	18[34]
HSC-45				Yes			[16]
HSC-57				Yes			[16]
HSC-59				Yes			[16]
KATOIII	ZO-1	Yes			1, 2, 4, 18		[38,71,72,111, 126,127]	11[119], 18[34]
MKN-1								4[126], 18[34]
MKN-7	ZO-1	Yes		Yes	4		[16,127]	18[34]
MKN-28	ZO-1	Yes	JAM-A		1, 3, 4, 7	Confluent monolayer with a TER	[64,71,72,126-128]	11[119], 18[34]
MKN-45	ZO-1	Yes			1, 2, 3, 4, 18	Isolated cell clumps	[34,71,72,108,111,127]
MKN-74				Yes	2, 4, 18		[16,34,37,38,111,126]	18[108]
MUGC4					1		[72]
NCI-N87	ZO-1				1, 4, 18	Confluent monolayer with a moderate TER	[38,66,71,126]
NUGC-3								18[108]
SIIA								11[119]
SCG-7901			JAM-A		1, 18		[19,38,71]
SNU-1								11[119]
SNU-5					4		[126]
SNU-216					4		[126]
SNU-484								4[126]
SNU-601					4		[126]
SNU-620					4		[126]
SNU-638								4[126]
SNU-668								4[126]
SNU-719					4		[126]
TMK-1	ZO-1				1, 3, 4, 7, 12, 15, 18		[129]	18[34]

Cldn: Claudin; ZO: Zonula occludens; TER: Transepithelial (electrical) resistance.