Topic Highlight
Copyright ©The Author(s) 2015.
World J Gastroenterol. Oct 28, 2015; 21(40): 11343-11352
Published online Oct 28, 2015. doi: 10.3748/wjg.v21.i40.11343
Table 1 Small interfering RNA therapies
Target geneDelivery systemAdministrationRef.
TNF-α siRNA therapy with delivery system
TNF-αTKNOral[14]
TNF-αPEI-PVAOral[15]
TNF-αNiMOSOral[16]
TNF-αOMe-POral[17]
TNF-αTPP-PPMEx vivo[18]
TNF-αFab'-bearing PLA-PEGOral[19]
siRNA therapy targeting other molecules with delivery system
CyD1Abs to β7 integrinIntravenous[22]
TNF-α/CyD1NiMOSOral[23]
Map4k4β1,3-D-glucan shellOral[24]
CD98scCD98-functionalizedOral[25]