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Copyright ©The Author(s) 2015.
World J Gastroenterol. Oct 28, 2015; 21(40): 11282-11303
Published online Oct 28, 2015. doi: 10.3748/wjg.v21.i40.11282
Table 4 Risk factors associated to primary failure
Crohn's diseaseUlcerative colitis
Duration of the disease > 2 yrOld age
SmokingAnti-neutrophil cytoplasmic (ANC) antibodies
Extensive small bowel involvementNegative antibodies against Saccharomyces cerevisiae
Low C-reactive protein levelsPrevious exposure to anti-TNF-α drugs
Genetic mutations or polymorphisms of the apoptosis and caspase 6 genes and locus IBD 5