Mixed adenoneuroendocrine carcinoma of gastrointestinal tract: Report of two cases

Figure 2 Gastric mixed adenoneuroendocrine carcinoma consists of mixed proliferation of glandular with specific immunoexpression. Solid tumor areas (A); The glandular structures are reactive for keratin AE1/AE3 (B) and solid structures express synaptophysin (C); A high Ki67 index can be seen in both tumor components (D); The nuclear expression of maspin in the glandular component (E) reflects the tumor aggressiveness that is confirmed by predominance of this component in lymph node metastases (F).