Prognostic implications of estrogen receptor 1 and vascular endothelial growth factor A expression in primary gallbladder carcinoma

Figure 4 Kaplan-Meier survival curves stratified for estrogen receptor 1 and vascular endothelial growth factor A expression. Patients with high expression of estrogen receptor1 (ER1) combined with vascular endothelial growth factor A (VEGF-A) (+/+) had worst prognosis than other groups (+/-,-/+,-/-) (P = 0.007). +/+: high ER1 expression and high VEGF-A expression; +/-: high ER1 expression and low VEGF-A expression; -/+: low ER1 expression and high VEGF-A expression; -/-: low ER1 expression and low VEGF-A expression.