Prognostic value of KRAS and BRAF mutations in curatively resected colorectal cancer

doi:10.3748/wjg.v21.i4.1275

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Jan 28, 2015; 21(4): 1275-1283
Published online Jan 28, 2015. doi: 10.3748/wjg.v21.i4.1275

Table 4 Prognostic Effects of KRAS and BRAF mutations according to microsatellite instability status

	KRAS		BRAF
	HR (95%CI)	P value	HR (95%CI)	P value
DFS¹
MSS/MSI-L	1.37 (1.05-1.80)	0.95	2.06 (0.96-4.43)	0.91
MSI-H	1.34 (0.34-5.24)		2.46 (0.49-12.4)
OS¹
MSS/MSI-L	1.49 (1.10-2.02)	0.70	2.74 (1.19-6.30)	0.44
MSI-H	1.39 (0.33-5.78)		1.18 (0.23-6.02)

¹Covariates include age, gender, AJCC stage (I-II/III), adjuvant chemotherapy, and KRAS and BRAF status. HR: Hazard ratio; CI: Confidence interval; DFS: Disease-free survival; OS: Overall survival; MSI: Microsatellite instability; MSS: Microsatellite stable; MSI-L: Microsatellite instability-low; MSI-H: Microsatellite instability-high.

Citation: Kadowaki S, Kakuta M, Takahashi S, Takahashi A, Arai Y, Nishimura Y, Yatsuoka T, Ooki A, Yamaguchi K, Matsuo K, Muro K, Akagi K. Prognostic value of KRAS and BRAF mutations in curatively resected colorectal cancer. World J Gastroenterol 2015; 21(4): 1275-1283
URL: https://www.wjgnet.com/1007-9327/full/v21/i4/1275.htm
DOI: https://dx.doi.org/10.3748/wjg.v21.i4.1275