Prognostic value of KRAS and BRAF mutations in curatively resected colorectal cancer

Table 3 Prognostic effects of microsatellite instability, KRAS, and BRAF status in Cox proportional models

	Disease-free survival1		Overall survival1
	HR (95%CI)	P value	HR (95%CI)	P value
MSI
MSS/MSI-L	1 (reference)	0.14	1 (reference)	0.53
MSI-H	0.64 (0.35-1.16)		0.81 (0.42-1.56)
KRAS
Wild-type	1 (reference)	0.03	1 (reference)	0.01
Mutant	1.35 (1.03-1.75)		1.46 (1.09-1.97)
BRAF
Wild-type	1 (reference)	0.01	1 (reference)	0.02
Mutant	2.20 (1.19-4.06)		2.30 (1.15-4.71)

¹Covariates include age (< 65 or ≥ 65), gender, AJCC stage (I/II/III), adjuvant chemotherapy (Yes/No), and MSI, KRAS, and BRAF status. CI: Confidence interval; MSI: Microsatellite instability; MSS: Microsatellite stable; MSI-L: Microsatellite instability-low; MSI-H: Microsatellite instability-high.