Prognostic value of KRAS and BRAF mutations in curatively resected colorectal cancer

doi:10.3748/wjg.v21.i4.1275

Advanced Search

BPG is committed to discovery and dissemination of knowledge

Home / Archive / Volume 21, Issue 4

This Article

Academic Content and Language Evaluation of This Article

Citation of this article

Corresponding Author of This Article

Research Domain of This Article

Article-Type of This Article

Open-Access Policy of This Article

Times Cited Counts in Google of This Article

Number of Hits and Downloads for This Article

Total Article Views (9527)

All Articles published online

The chart showing PDF series, WORD series, HTML series, Figures (1-2) series, Tables (1-4) series.

Item

Count

PDF

780

WORD

304

HTML

5263

Figures (1-2)

237

Tables (1-4)

207

Sum=6791

Publishing Process of This Article

The chart showing Browse series, Download series.

Item

Count

Browse

1265

Download

1471

Sum=2736

Jan 28, 2015 (publication date) through Feb 4, 2025

Times Cited of This Article

Times Cited (61)

Journal Information of This Article

Publication Name

World Journal of Gastroenterology

ISSN

1007-9327

Publisher of This Article

Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Observational Study

World J Gastroenterol. Jan 28, 2015; 21(4): 1275-1283
Published online Jan 28, 2015. doi: 10.3748/wjg.v21.i4.1275

Table 2 Univariate prognostic analysis of disease-free survival and overall survival

Characteristics	Disease-free survival		Overall survival
Characteristics	HR	95%CI	HR	95%CI
Age (yr)
< 65	1	Reference	1	Reference
≥ 65	1.73	1.35-2.28	2.21	1.64-2.98
Gender
Female	1	Reference	1	Reference
Male	1.57	1.20-2.06	1.57	1.16-2.13
Tumor location
Proximal	1	Reference	1	Reference
Distal	0.92	0.67-1.25	0.9	0.64-1.26
Rectum	1.17	0.85-1.62	0.97	0.67-1.40
Histological grade
Well/moderate	1	Reference	1	Reference
Poor/mucinous	1.53	0.97-2.42	1.43	0.84-2.42
AJCC stage
I	1	Reference	1	Reference
II	2.6	1.61-4.19	2.26	1.36-3.75
III	4.68	2.95-7.42	3.49	2.14-5.70
Adjuvant chemotherapy
No	1	Reference	1	Reference
Yes	1.24	0.96-1.60	1.29	1.10-1.51
MSI
MSS/MSI-L	1	Reference	1	Reference
MSI-H	0.71	0.42-1.20	0.92	0.54-1.59
KRAS
Wild-type	1	Reference	1	Reference
Mutant	1.35	1.04-1.74	1.44	1.08-1.92
BRAF
Wild-type	1	Reference	1	Reference
Mutant	1.38	0.82-2.32	1.57	0.90-2.76

HR: Hazard ratio; CI: Confidence interval; MSI: Microsatellite instability; MSS: Microsatellite stable; MSI-L: Microsatellite instability-low; MSI-H: Microsatellite instability-high.

Citation: Kadowaki S, Kakuta M, Takahashi S, Takahashi A, Arai Y, Nishimura Y, Yatsuoka T, Ooki A, Yamaguchi K, Matsuo K, Muro K, Akagi K. Prognostic value of KRAS and BRAF mutations in curatively resected colorectal cancer. World J Gastroenterol 2015; 21(4): 1275-1283
URL: https://www.wjgnet.com/1007-9327/full/v21/i4/1275.htm
DOI: https://dx.doi.org/10.3748/wjg.v21.i4.1275