Prognostic implications of estrogen receptor 1 and vascular endothelial growth factor A expression in primary gallbladder carcinoma

Table 4 Multivariate analysis of factors associated with survival in patients with gallbladder carcinoma

Item	Hazard ratio	95% CI	P-value
Age, yr			0.076
≤ 55 vs > 55	0.615	0.359-1.053
TNM stage			0.031
III/IV vs II	1.781	1.054-3.011
ER1 combined with VEGF-A			0.042
+/+ vs +/-, -/+, -/-	1.773	1.021-3.080

ER1: Estrogen receptor 1; VEGF-A: Vascular endothelial growth factor; TNM: Tumor node metastasis; +/+: High ER1 expression and high VEGF-A expression; +/-: High ER1 expression and low VEGF-A expression; -/+: Low ER1 expression and high VEGF-A expression; -/-: Low ER1 expression and low VEGF-A expression.