Optimal duration of the early and late recurrence of hepatocellular carcinoma after hepatectomy

Table 3 Results of the univariate and multivariate analyses of the clinicopathologic factors

	Total (n)	Late group (n = 145)	Without recurrence (n = 91)	Univariate analysis P	Multivariate analysis
					RR (95%CI)	P
Age (yr)				0.125
< 60	95	64	31
≥ 60	141	81	60
Sex				0.194
Male	189	120	69
Female	47	25	22
Indocyanine green retention rate at 15 min				0.008
< 10%	70	34	36
≥ 10%	166	111	55
Underlying liver disease				0.002		0.002
Other	123	64	59		1
Cirrhosis	113	81	32		2.333 (1.359, 4.008)
Alpha-fetoprotein (ng/mL)				0.199
< 100	187	111	76
≥ 100	49	34	15
Number of tumors				0.069
Single	194	114	80
Multiple	42	31	11
Growth pattern				0.878
Expanding	225	138	87
Infiltrating	11	7	4
Capsule				0.905
Absent	45	28	17
Present	191	117	74
Serosal invasion				0.411
Negative	216	131	85
Positive	20	14	6
Microvascular invasion				0.641
Absent	199	121	78
Present	37	24	13
Surgical margin				0.703
Negative	224	137	87
Positive	12	8	4
Tumor size (mm)				0.113
< 50	193	114	79
≥ 50	43	31	12

The results of the univariate and multivariate analyses of the clinicopathologic factors contributing to late recurrence in the 236 patients who were confirmed to be recurrence-free at 17 mo after the initial hepatectomy for hepatocellular carcinoma.