Optimal duration of the early and late recurrence of hepatocellular carcinoma after hepatectomy

Table 2 Results of the univariate and multivariate analyses of the clinicopathologic factors

	Total (n)	Early group (n = 107)	Others (n = 297)	Univariate analysis P	Multivariate analysis
					RR (95%CI)	P
Age (yr)				0.290
< 60	175	51	124
≥ 60	229	56	173
Sex				0.933
Male	316	84	232
Female	88	23	65
Indocyanine green retention rate at 15 min				0.193
< 10%	110	24	86
≥ 10%	294	83	211
Underlying liver disease				0.225
Other	194	46	148
Cirrhosis	210	61	149
Alpha-fetoprotein (ng/mL)				< 0.001		< 0.001
< 100	280	52	228		1
≥ 100	124	55	69		2.939 (1.788, 4.830)
Number of tumors				< 0.001		< 0.001
Single	306	63	243		1
Multiple	98	44	54		2.633 (1.548, 4.445)
Growth pattern				0.002
Expanding	372	91	281
Infiltrating	32	16	16
Capsule				0.230
Absent	82	26	56
Present	322	81	241
Serosal invasion				0.006		0.031
Negative	358	87	271		1
Positive	46	20	26		2.110 (1.069, 4.164)
Microvascular invasion				< 0.001		0.012
Absent	312	64	248		1
Present	92	43	49		2.001 (1.163, 3.441)
Surgical margin				0.081
Negative	374	95	279
Positive	30	12	18
Tumor size (mm)				0.010
< 50	312	73	239
≥ 50	92	34	58

The results of the univariate and multivariate analyses of the clinicopathologic factors contributing to early recurrence after the initial hepatectomy for hepatocellular carcinoma.