Optimal duration of the early and late recurrence of hepatocellular carcinoma after hepatectomy

Table 1 Results of the univariate and multivariate analyses of prognostic factors

	Total (n)	5-yr OS after initial recurrence	MST (mo)	Univariate analysis P	Multivariate analysis
					Hazard ratio (95%CI)	P
Age (yr)				0.726
< 60	115	29.9%	30.6
≥ 60	137	24.1%	32.3
Sex				0.464
Male	204	26.3%	30.6
Female	48	32.7%	38.1
Indocyanine green retention rate at 15 min				0.023		0.021
< 10%	58	47.4%	41.1		1
≥ 10%	194	21.3%	28.4		1.680 (1.081, 2.613)
Underlying liver disease				0.017		0.048
Other	110	37.3%	39.7		1
Cirrhosis	142	20.0%	27.4		1.422 (1.003, 2.017)
Alpha-fetoprotein (ng/mL)				0.010
< 100	163	29.4%	35.8
≥ 100	89	23.1%	21.3
Type of resection				0.561
Non-anatomical resection	52	17.5%	33.4
Anatomical resection	200	28.5%	28.5
Number of tumors				0.009		0.021
Single	177	31.7%	37.6		1
Multiple	75	17.0%	21.6		1.530 (1.066, 2.196)
Growth pattern				0.001		0.008
Expanding	229	28.8%	33.9		1
Infiltrating	23	12.4%	14.3		1.963 (1.191, 3.234)
Histological differentiation				0.001
Poorly differentiated	27	10.6%	11.1
Others	225	28.7%	35.7
Capsule				0.242
Absent	54	13.1%	25.4
Present	198	31.5%	33.4
Serosal invasion				0.905
Negative	218	26.2%	33.3
Positive	34	31.7%	21.6
Microvascular invasion				0.012
Absent	185	27.0%	35.7
Present	67	26.8%	14.4
Surgical margin				0.839
Negative	232	26.7%	28.7
Positive	20	34.3%	48.7
Tumor size (mm)				0.182
< 50	187	25.0%	26.9
≥ 50	65	20.3%	16.6
Recurrence period				< 0.001		0.001
Early group (< 17 mo)	107	15.4%	19.2		1.735 (1.237, 2.432)
Late group (≥ 17 mo)	145	36.3%	41.1		1

The results of the univariate and multivariate analyses of prognostic factors associated with overall survival after initial recurrence in the 252 patients who developed recurrence of hepatocellular carcinoma (HCC) after hepatectomy for HCC. MST: Median survival time.