Factors associated with significant liver fibrosis assessed using transient elastography in general population

Table 3 Comparison between patients with and without significant liver fibrosis (> 7 kPa)

Variables	Patients without significant fibrosis [n = 148 (93.1%), LS value ≤7 kPa]	Patients with significant fibrosis [n = 11 (6.9%), LS value > 7 kPa]	P value
Age, yr	55.5 ± 10.4	63.2 ± 11.5	NS
Male gender	80 (54.1)	7 (63.6)	NS
Body mass index, kg/m2	24.1 ± 3.0	27.5 ± 3.0	0.001
Diabetes mellitus	17 (11.5)	2 (18.2)	NS
Hypertension	38 (25.7)	2 (18.2)	NS
Daily alcohol intake, mg	16.2 ± 31.7	11.0 ± 16.4	NS
Alanine aminotransferase, IU/L	22.2 ± 11.4	32.3 ± 17.1	0.024
Platelet count, 109/L	235.6 ± 55.5	234.2 ± 92.0	NS
Fasting plasma glucose, mg/dL	99.7 ± 24.3	106.1 ± 24.9	NS
HOMA-IR	1.7 ± 1.2	2.9 ± 2.0	0.034
HbA1c, %	6.0 ± 0.7	6.2 ± 0.6	NS
Presence of fatty liver on Sonography, n	53 (35.8%)	9 (81.8%)	0.004
Intimal media thickness, mm	0.7 ± 0.2	1.4 ± 2.1	0.011
Presence of carotid plaque	31 (20.9)	3 (27.3)	NS
Calcified carotid plaque, n	0.4 ± 1.0	1.5 ± 1.8	0.019
Visceral fat area, cm2	107.2 ± 47.7	171.5 ± 93.0	0.002
Controlled attenuation parameter, dB/m	246.4 ± 43.8	266.7 ± 45.6	NS

Values are expressed as the mean ± SD (range), median (range), or n (%). NS: Not significant; LS: Liver stiffness; HOMA-IR: Homeostasis model assessment of insulin resistance; HbA1c: Glycated hemoglobin.