Loss of stromal caveolin-1 expression in colorectal cancer predicts poor survival

Table 3 Univariate and multivariate analyses of prognostic factors in colorectal cancer with respect to overall survival and disease-free survival

Parameter	Univariate analysisP-value	Multivariate analysisHR (95%CI)	P-value
OS
Age (> 50)	0.185	-	1.632
Gender	0.794	-	1.431
Tumor location	0.384	-	1.414
Tumor cell Cav-1	0.216	-	0.742
Stromal Cav-1	< 0.001a	0.578 (0.373-0.895)	0.014a
Tumor size	0.443	-	0.382
Histological type	0.533	-	0.666
Pathological T stage	0.067	-	0.347
Pathological N stage	< 0.001a	-	0.868
TNM	0.025a	-	0.378
Recurrence	< 0.001a	2.065 (1.121-3.803)	< 0.001a
DFS
Age (> 50)	0.165	-	0.218
Gender	0.664	-	0.833
Tumor location	0.061	-	0.325
Tumor cell Cav-1	0.189	-	0.705
Stromal Cav-1	< 0.001a	0.546 (0.353-0.844)	0.006a
Tumor size	0.603	-	0.511
Histological type	0.478	-	0.553
Pathological T stage	0.171	-	0.888
Pathological N stage	0.002a	-	0.510
TNM	0.184	0.451 (0.233-0.874)	0.018a
Recurrence	< 0.001a	1.863 (1.106-2.434)	< 0.001a

^aP < 0.05, univariate analysis vs multivariate analysis. CAV-1: Caveolin-1; TNM: Tumor-node-metastasis; OS: Overall survival; DFS: Disease-free survival.