Genetic background in nonalcoholic fatty liver disease: A comprehensive review

Table 1 Genetic variants involved in susceptibility and/or progression of nonalcoholic fatty liver disease identified by genome-wide association studies

Gene	SNP	Association with
PNPLA3, patatine-like phospholipase domain containing 3	rs738409	Steatosis
		NASH/necroinflammation
		Severity of fibrosis
		HCC development
TM6SF2, transmembrane 6 superfamily member 2	rs58542926	Steatosis
		NASH/necroinflammation
		Severity of fibrosis
		Reduced cardiovascular risk
NCAN, neurocan	rs2228603	Steatosis
PPP1R3B, protein phosphatase 1 regulatory subunit 3b	rs4240624	Steatosis
GCKR, glucokinase regulatory protein	rs780094	Steatosis
		Severity of fibrosis
LYPLAL1, lysophospholipase-like 1	rs12137855	Steatosis
FDFT1, farnesyl diphosphate farnesyl transferase 1	rs2645424	NAFLD activity score
PDGFA, platelet-derived growth factor alpha	rs343062	Severity of fibrosis
COL13A1, collagen type XIII alpha1	rs1227756	Lobular inflammation
LTBP3, latent transforming growth factor-beta-protein 3	rs6591182	Lobular inflammation
EFCAB4B, EF-hand calcium binding domain 4B	rs887304	Lobular inflammation

SNP: Single nucleotide polymorphism; NASH: Nonalcoholic steatohepatitis; NAFLD: Nonalcoholic fatty liver disease; HCC: Hepatocellular carcinoma.