Posttransplant lymphoproliferative disorders following liver transplantation: Where are we now?

Table 1 World Health Organization classification posttransplant lymphoproliferative disorder

	Early lesions	Polymorphic PTLD	Monomorphic PTLD
Underlying architecture	(Partially) preserved	Destructed	Destructed
Cells	Plasma cells, small lymphocytes and immunoblasts	Complete spectrum of B cell maturation	Fulfill criteria for lymphoma
Immunohistochemistry	No diagnostic value	Mixture of B and T cells	Most cases CD20 positive
EBV	100%	> 90%	+/- 70%
Clonality	In most cases polyclonal	Variable	Monoclonal
Oncogenic mutations	No	Variable (BCL6)	Oncogenes (N-Ras, c-MYC,…) and tumor suppressor genes (p53,…)

PTLD: Posttransplant lymphoproliferative disorder; EBV: Epstein Barr virus.