Clinical significance of donor-specific human leukocyte antigen antibodies in liver transplantation

doi:10.3748/wjg.v21.i39.11016

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Oct 21, 2015 (publication date) through Jan 27, 2025

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Oct 21, 2015; 21(39): 11016-11026
Published online Oct 21, 2015. doi: 10.3748/wjg.v21.i39.11016

Table 2 Diagnostic criteria of acute antibody-mediated rejection in liver transplantation

The presence of DSA in serum

Histopathologic evidence of diffuse microvascular endothelial cell injury and microvasculitis

Strong and diffuse C4d positivity in tissue¹

Reasonable exclusion of other causes of injury that might result in similar findings

¹Diffuse portal microvascular positivity in formalin-fixed, paraffin-embedded samples (although detection of C4d is more sensitive in fresh tissue) is emerging as most strongly correlated with donor-specific anti-HLA antibodies-induced injury. DSA: Donor-specific anti-HLA antibodies.

Citation: Cuadrado A, San Segundo D, López-Hoyos M, Crespo J, Fábrega E. Clinical significance of donor-specific human leukocyte antigen antibodies in liver transplantation. World J Gastroenterol 2015; 21(39): 11016-11026
URL: https://www.wjgnet.com/1007-9327/full/v21/i39/11016.htm
DOI: https://dx.doi.org/10.3748/wjg.v21.i39.11016