Epidemiology of hepatitis C virus in Iran

Table 8 Distribution of hepatitis C virus genotypes among hepatitis C virus -infected patients in Iran n (%)

Study group	City or province	Location	Year of study	Sample size	Genotype 1	Genotype 2	Genotype 3	Genotypes 4 and 5	Mixed genotype	Non typable	Method	Author	Ref.
Blood donors	Ahvaz	South-West	2007-2008	45	1a: 24 (53.3)		3a: 21 (46.7)				RFLP	Farshadpour	[233]
Blood donors	Tehran	North-Center	2006-2008	103	1a: 53 (51.5)		3a: 39 (37.9)			7 (6.8)	Type-specific primers	Sharifi	[234]
					1b: 4 (3.9)
General population	Iran	Iran	2000-2005	116	1a: 71 (61.2)		3a: 29 (25.0)				RFLP	Amini	[235]
					1b: 16 (13.8)
General population	Iran	Iran	2004-2007	206	1a: 53 (25.73)	2: 4 (1.95)	3a: 96 (46.60)		11 (5.34)	6 (2.91)	PCR kit	Hajia	[236]
					1b: 36 (17.47)
General population	Isfahan	Center	2007-2009	97	1a: 29 (29.5)	2: 2 (2.0)	3a: 59 (61.2)		2 (2.0)		PCR based genotyping kit	Zarkesh-Esfahani	[237]
					1b: 5 (5.1)
General population	Zanjan	West	2007-2013	ND	1a: 22.05%	2: 5.14%	3a: 38.26%	4: 4.41%		4.41%	LiPA	Esmaeilzadeh	[238]
					1b: 25.73%
General population	Yazd	Center	2010-2013	191	1a: 74 (38.7)	2: 3 (1.6)	3: 96 (50.3)		5 (2.6)		PCR based genotyping kit	Hadinedoushan	[239]
					1b: 13 (6.8)
General population	Mashhad	North-East	2009-2010	382	1a: 147 (39.2)	2a: 9 (2.4)	3a: 150 (40.0)	5: 13(3.4)			Genotype specific primers	Vossughinia	[240]
					1b: 41(10.9)
General population	Tehran	North-Center	2007	2231	1a: 886 (39.7)		3a: 613 (27.5)		33 (1.6)	401 (18.0)	Genotype specific primers	Keyvani	[241]
					1b: 271 (12.1)
General population	Golestan	North	2010	77	1a: 15 (19.5)	2a: 2 (2.6)	3a: 12 (15.6)	4: 6 (7.8)	8 (6.5)		Genotype specific primers	Moradi	[242]
					1b: 15(19.5)		3b: 19 (24.7)
General population	Ahvaz	South-West	2009	80	1a: 43 (53.8)		3a: 37 (46.2)				RFLP	Hamidi-Fard	[243]
Thalassemia	Mazandaran	North	2009-2011	34	1a: 13 (38.24)		3a: 15 (44.12)		4 (11.76)	1 (2.94)	Type-specific primer	Rafiei	[244]
					1b: 1 (2.94)
Thalassemia	Mazandaran and Guilan	North	2010	28	1a: 9 (32.1)		3a: 18 (64.3)				RFLP	Ghane	[245]
					1b: 1 (3.6)
Thalassemia	Fars	South	2009-2012	38	1: 17 (44.7)		3: 6 (15.8)			15 (39.5)	Real-time PCR	Jamalidoust	[231]
Haemophilia	Mazandaran	North	2009-2011	33	1a: 7 (21.21)		3a: 25 (75.76)			1 (3.03)	Type-specific primer	Rafiei	[244]
Haemophilia	Fars	South	2009-2012	8	1: 5 (62.5)		3: 1 (12.5)			2 (25.0)	Real-time PCR	Jamalidoust	[231]
Haemophilia	Ahvaz	South-West	2008-2009	42	1a: 26 (61.9)		3a: 5 (11.9)				Genotype specific primers	Assarehzadegan	[131]
					1b: 11 (26.1)
Haemophilia	Markazi	West-Center	2004	22	1: 6 (27.3)	2: 1 (4.54)	3a: 4 (18.2)		6 (27.3)		LiPA	Samimi-Rad	[128]
					1a: 3 (13.6)
					1b: 2 (9.1)
IDUs	Mazandaran	North	2009-2011	37	1a: 11 (29.73)		3a: 5 (13.51)		11 (29.73)		Type-specific primer	Rafiei	[244]
					1b: 10 (27.03)
IDUs	Tehran	North-Center	2008-2009	36	1a: 9 (25)		3a: 21 (58.3 )				Type-specific primers	Ranjbar Kermani	[246]
					1b: 6 (16.7)
IDUs	Fars	South	2009-2012	550	1: 283 (51.5)		3: 192 (34.9)		8 (12.2)	67 (12.2)	Real-time PCR	Jamalidoust	[231]
IDUs	Tehran	North-Center	2008-2009	83	1a: 35 (42)		3a: 48 (58.0)				Sequencing	Samimi-Rad	[247]
Haemodialysis	Mazandaran	North	2009-2011	31	1a: 6 (19.36)		3a: 24 (77.42)		1 (3.22)		Type-specific primer	Rafiei	[244]
Haemodialysis	Markazi	West-Center	2005	8	1a: 4 (50)		3a: 1 (12.5)	4: 2 (25)			LiPA	Samimi-Rad	[102]
					1b: 1 (12.5)
Haemodialysis	Fars	South	2009-2012	6	1: 4 (66.7)			4: 1(16.7)		1 (16.7)	Real-time PCR	Jamalidoust	[231]
Haemodialysis	East Azerbaijan	North-West	2006	55	1a: 42 (76.4)		3a: 3 (5.5)		1 (1.8)	4 (10.9)	Type-specific primer	somi	[248]
					1b: 3 (5.5)
Haemodialysis	Gilan	North	2008	32	1a: 19 (59.4)		3a: 13 (40.6)				Genotype-specific primers	Joukar	[101]
Haemodialysis	Tehran	North-Center	2004	66	1a: 19 (28.8)		3a: 20 (30.3)	4:11(16.7)	2 (3.0)		RFLP	Hosseini-Moghaddam	[249]
					1b: 12 (18.2)		3b: 2 (3.0)
HIV/HCV co-infection	Shiraz	South	2004-2005	50	1a: 20 (40)		3a: 17 (34.0)				RFLP	Davarpanah	[250]
					1b: 13 (26)
Occult HCV infected patients	Tehran	North-Center	2007-2010	7	1a: 2 (29)		3a: 2 (29.0)				RFLP	Bokharaei-Salim	[251]
					1b: 3 (43)

ND: Not defined.