Impact of new treatment options for hepatitis C virus infection in liver transplantation

Table 3 Pros and cons of hepatitis C virus treatment before and after liver transplant

	Before LT	After LT
Aim	Prevention of HCV recurrence	Treatment of HCV recurrence
Advantages	Undetectable HCV-RNA at transplantation correlates with low rates of post-LT HCV recurrence	Increased tolerance to treatment
Disadvantages	Low eligibility due to compromised baseline conditions	High rates of adverse effects
	High rates of serious side effects and discontinuation rates	Moderate SVR rates
	Low SVR rates	Drug-drug interactions

HCV: Hepatitis C virus; LT: Liver transplant; SVR: Sustained virological response.