Jejunitis and brown bowel syndrome with multifocal carcinogenesis of the small bowel

Figure 2 Disease progression. A: Push enteroscopy and high-pressure balloon dilatation of the stenosis were performed; Histology indicated the development of an B: Adenoma; and D: Carcinoma. Thus, 20 years of persistent inflammation led to malignancy according to an enteritis-dysplasia-adenocarcinoma sequence; C: Unaffected crypts showed strong nuclear MLH1 expression, while neoplastic tissue failed to express MLH1. Histological sections A-D were prepared with hematoxylin-eosin staining (magnification × 40) and additional immunohistochemistry was performed.