Recql5 protects against lipopolysaccharide/D-galactosamine-induced liver injury in mice

Figure 1 Enhanced lipopolysaccharide/D-Gal-induced liver injury in Recql5-deficient mice. A: Survival curves after lipopolysaccharide (LPS)/D-Gal injection. Wild type (WT) and Recql5-deficient (Recql5^-/-) mice were treated with 20 μg/kg LPS and 400 mg/kg D-Gal (WT, n = 14; KO, n = 16). Survival curves were created using the Kaplan-Meier method and compared by log-rank (Mantel-Cox) test; B: Images of the whole livers demonstrate the different degree of hemorrhage. WT and Recql5-deficient mice were treated with 300 mg/kg D-Gal and 10 μg/kg LPS (n = 4-7 per group). Livers were removed 6 h after injection; C: HE staining of liver sections 6 h after injection; D: Serum alanine transaminase (ALT) activity 6 h after injection; E: Serum aspartate transaminase (AST) activity 6 h after treatment. ^bP < 0.01, WT vs Recql5^-/-.