Ursodeoxycholic acid induces apoptosis in hepatocellular carcinoma xenografts in mice

Figure 1 Ursodeoxycholic acid suppresses tumor growth in vivo. A: Tumor volume is plotted as a function of time in days. Tumor volumes plotted represent the median value of xenografts from 10 animals in each group; B: The median value of the tumor volume for each group after 21 d of treatment are graphically depicted. Differences between control and treated xenografts on day 21 reached statistical significance (P < 0.05) at all ursodeoxycholic acid (UDCA) doses (30 mg/kg per day, ^aP < 0.05; 50 mg/kg per day, ^bP < 0.05; 70 mg/kg per day, ^cP < 0.01).