Chemoembolization alone vs combined chemoembolization and hepatic arterial infusion chemotherapy in inoperable hepatocellular carcinoma patients

Table 3 Univariate and multivariate prognostic analyses of the patients (n = 79)

Correlative factor	Number of cases	Kaplan-Meier univariate analysis			Cox multivariate analysis
		mPFS (mo)	95%CI	P-value	Sig	EXP(B)	95%CI
Interventional therapy				0.00049	0.00048	0.26	0.174-0.612
Chemoembolization	37	4.5	3.3-5.7
Chemoembolization combined with HAIC	42	8.0	7.2-8.8
Grading of physical condition				0.00014	0.312	1.525	0.674-3.452
PS = 0	40	8.9	6.2-11.5
PS = 1	39	4.5	3.7-5.2
Vascular invasion1				0.00047	0.050	1.963	0.989-3.898
No	52	7.9	7.3-8.5
Yes	27	3.8	2.7-4.8
BCLC Stage2				0.00051	0.003	3.083	1.479-6.426
Stage C	30	3.8	3.0-4.6
Stage A or B	39	9.3	6.7-11.9
AFP (ng/mL)				0.03	0.488	1.255	0.660-2.386
< 400	52	7.3	5.8-8.8
≥ 400	27	4.5	2.1-7.0
Sum of tumor target lesion diameter (cm)				0.00011	0.326	1.449	0.691-3.338
≤ 10	45	7.8	6.1-9.5
> 10	34	4.3	3.2-5.3
Serum albumin (g/L)				0.027	0.27	0.628	0.275-1.434
< 35	7	4.3	3.0-5.6
≥ 35	72	7.3	5.9-8.6

¹Venous invasion refers to portal vein or hepatic vein tumor thrombosis, APVS;

²BCLC staging did not include patients who relapsed after surgery. PFS: Progression free survival; mPFS: Median progression free survival; AFP: Alpha-fetoprotein; HAIC: Hepatic arterial infusion chemotherapy; BCLC: Barcelona Clinic Liver Cancer staging.