TP53 codon 72 Arg/Arg polymorphism is associated with a higher risk for inflammatory bowel disease development

doi:10.3748/wjg.v21.i36.10358

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Sep 28, 2015 (publication date) through Dec 28, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Sep 28, 2015; 21(36): 10358-10366
Published online Sep 28, 2015. doi: 10.3748/wjg.v21.i36.10358

Table 2 Allele frequencies of TP53⁷²Arg/Pro polymorphism in cases and controls n (%)

Patients/Controls	Allele		P value¹
Patients/Controls	Arg	Pro
Cases (n = 642):	974 (75.9)	310 (24.1)	P value¹	< 0.0001
UC Adult (n = 151)	222 (73.5)	80 (26.5)	0.0029
CD Adult (n = 138)	210 (76.1)	66 (23.9)	0.0005
UC Pediatric (n = 78)	118 (75.6)	38 (24.4)	0.0028
CD Pediatric (n = 94)	145 (77.1)	43 (22.9)	0.0006
PSC (n = 42)	67 (79.8)	17 (20.2)	0.0016
PSC + UC (n = 139)	212 (76.3)	66 (23.7)	0.0004
Controls (n = 62)	73 (58.9)	51 (41.1)

¹P value calculated by χ² test for comparison of patient groups with controls.

Citation: Volodko N, Salla M, Eksteen B, Fedorak RN, Huynh HQ, Baksh S. TP53 codon 72 Arg/Arg polymorphism is associated with a higher risk for inflammatory bowel disease development. World J Gastroenterol 2015; 21(36): 10358-10366
URL: https://www.wjgnet.com/1007-9327/full/v21/i36/10358.htm
DOI: https://dx.doi.org/10.3748/wjg.v21.i36.10358