Hepatitis B virus reactivation associated with antirheumatic therapy: Risk and prophylaxis recommendations

doi:10.3748/wjg.v21.i36.10274

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Sep 28, 2015; 21(36): 10274-10289
Published online Sep 28, 2015. doi: 10.3748/wjg.v21.i36.10274

Table 1 Definition of resolved hepatitis B virus infection, inactive carrier state, chronic hepatitis B, and immunization due to vaccination

	HBsAg	Anti-HBs	HBeAg	Anti-HBe	Anti-HBc	ALT	HBV-DNA in serum (copies/mL)	HBV-DNA in the liver	Liver injury
Resolved infection	-	+/-	-	+/-	+/-	Normal	Negative	+	No
Inactive carriers	+	-	-	+	+	Normal	Negative to 10⁴	+	No
Chronic hepatitis B	+	-	+	-	+	Elevated	> 10⁵	+	Yes
(HBeAg-positive)	+	-	+	-	+	Elevated	> 10⁵	+	Yes
Chronic hepatitis B	+	-	-	+	+	Elevated	> 10⁴	+	Yes
(HBeAg-negative)	+	-	-	+	+	Elevated	> 10⁴	+	Yes
Immunized	-	+	-	-	-	Normal	Negative	-	No

HBV: Hepatitis B virus; HBsAg: Hepatitis B surface antigen; anti-HBs: Anti-hepatitis B surface antibody; HBeAg: Hepatitis B e antigen; anti-HBe: Anti-hepatitis B e antibody; anti-HBc: Anti-hepatitis B core antibody; ALT: Alanine aminotransferase.

Citation: Mori S, Fujiyama S. Hepatitis B virus reactivation associated with antirheumatic therapy: Risk and prophylaxis recommendations. World J Gastroenterol 2015; 21(36): 10274-10289
URL: https://www.wjgnet.com/1007-9327/full/v21/i36/10274.htm
DOI: https://dx.doi.org/10.3748/wjg.v21.i36.10274