Effect of tumor necrosis factor-α antagonists on oxidative stress in patients with Crohn’s disease

Table 3 Correlations between d-ROM, BAP, m-OA, CDAI, serum CRP, WBC, and serum albumin in Crohn’s disease patients treated with anti-TNF-α

Oxidative markers	Clinical parameters	r	P value
d-ROM	CDAI
	Before	0.42	< 0.01
	After	0.33	0.03
	CRP
	Before	0.64	< 0.01
	After	0.53	< 0.01
	WBC
	Before	0.12	0.47
	After	0.03	0.84
	Alb
	Before	-0.33	0.03
	After	-0.38	0.01
BAP	CDAI
	Before	-0.17	0.28
	After	-0.18	0.24
	CRP
	Before	0.03	0.85
	After	0.12	0.44
	WBC
	Before	-0.04	0.79
	After	0.01	0.95
	Alb
	Before	0.24	0.13
	After	0.14	0.38
m-OA	CDAI
	Before	-0.48	< 0.01
	After	-0.42	< 0.01
	CRP
	Before	-0.63	< 0.01
	After	-0.45	< 0.01
	WBC
	Before	-0.20	0.21
	After	-0.01	0.73
	Alb
	Before	0.45	< 0.01
	After	0.47	< 0.01

TNF: Tumor necrosis factor; m-OA: Modified ratio of oxidative stress and antioxidant capacity; BAP: Biological antioxidant potential; d-ROM: Diacron-reactive oxygen metabolite; CDAI: Crohn’s disease activity index.