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©The Author(s) 2015.
World J Gastroenterol. Sep 21, 2015; 21(35): 10150-10158
Published online Sep 21, 2015. doi: 10.3748/wjg.v21.i35.10150
Published online Sep 21, 2015. doi: 10.3748/wjg.v21.i35.10150
Table 6 Haplotypic distribution of the 2 SNPs of CTLA-4 gene in different studied groups n (%)
| SNPs | Controls | Patients | G1 | G2 | Persistence | Clearance |
| (n = 358) | (n = 500) | (n = 240) | (n = 260) | (n = 159) | (n = 148) | |
| (+49) A/G CTLA4 | ||||||
| Genotypes | ||||||
| AA | 40 (11.2) | 77 (15.4) | 43 (17.9) | 34 (13.1) | 25 (15.7) | 19 (12.84) |
| AG | 142 (39.7) | 198 (39.6) | 93 (38.8) | 105 (40.4) | 66 (41.5) | 54 (36.5) |
| GG | 176 (49.2) | 225 (45) | 104 (43.3) | 121 (46.5) | 68 (42.8) | 75 (50.7) |
| Alleles | ||||||
| A | 0.31 | 0.352 | 179 (37.3) | 173 (33.3) | 116 (36.5) | 92 (31.1) |
| G | 0.69 | 0.648 | 301 (62.7) | 347 (66.7) | 202 (63.5) | 204 (68.9) |
| (+6230) G/A CTLA4 | ||||||
| Genotypes | ||||||
| GG | 124 (34.6) | 194 (38.8) | 97 (40.4) | 97 (37.3) | 65 (40.9) | 55 (37.2) |
| GA | 158 (44.1) | 217 (43.4) | 102 (42.5) | 115 (44.2) | 66 (41.5) | 64 (43.2) |
| AA | 76 (21.3) | 89 (17.8) | 41 (17.1) | 48 (18.5) | 28 (17.6) | 29 (19.6) |
| Alleles | ||||||
| G | 0.567 | 0.605 | 296 (61.7) | 309 (59.4) | 196 (61.6) | 174 (58.8) |
| A | 0.433 | 0.395 | 184 (38.3) | 211 (40.6) | 122 (38.4) | 124 (41.2) |
- Citation: Ksiaa Cheikhrouhou L, Lakhoua-Gorgi Y, Sfar I, Jendoubi-Ayed S, Aouadi H, Makhlouf M, Ayed K, Ben Abdallah T. Natural evolution of hepatitis C virus infection in hemodialysis Tunisian patients and CTLA-4 SNP's. World J Gastroenterol 2015; 21(35): 10150-10158
- URL: https://www.wjgnet.com/1007-9327/full/v21/i35/10150.htm
- DOI: https://dx.doi.org/10.3748/wjg.v21.i35.10150