Broccoli sprout extract induces detoxification-related gene expression and attenuates acute liver injury

Table 6 Hepatoprotective effects of broccoli sprout extract on APAP-induced liver injury

Marker	Control		BSEx		APAP		APAP + BSEx
	Mean	SD	Mean	SD	Mean	SD	Mean	SD
Body weight (g)	188.45	10.38	190.90	11.36	172.39	9.91	183.63	8.87
Body weight gain after i.p (g)	3.88	1.77	3.59	1.53	-11.21a	3.30	-1.05b	2.84
Liver weight (g)	8.46	0.44	9.13	0.69	6.90a	0.58	8.11d	0.85
Liver/body	0.045	0.001	0.048	0.002	0.04a	0.002	0.044d	0.003
AST (IU/L)	71.41	6.99	59.98	8.46	5614.41a	1997.83	70.91	15.74
ALT (IU/L)	12.51	0.57	9.81	1.84	1297.71a	447.33	11.78	2.08
GST activity (U/g tissue)	61.78	4.95	77.89	4.62	51.90c	16.85	93.19b	16.55
TBARS (μmol/g tissue)	462.68	36.57	420.95	23.66	751.12a	220.87	496.63	37.21
GSH (nmol/g tissue)	2.73	0.26	2.99	0.29	1.66a	0.59	2.61	0.75

^aP < 0.05 vs Control, BSEx, APAP + BSEx;

^bP < 0.05 vs Control, BSEx, APAP;

^cP < 0.05 vs BSEx, APAP + BSEx;

^dP < 0.05 vs BSEx, APAPBSEx: Broccoli sprout extract; AST: Aspartate transaminase; ALT: Alanine transaminase; GSH: Hepatic glutathione; GST: Glutathione-S-transferase.