Broccoli sprout extract induces detoxification-related gene expression and attenuates acute liver injury

Table 4 Significant canonical pathways (P < 0.05) in upregulated genes induced by broccoli sprout extract

Ingenuity canonical pathways	-log(B-H P value)	Ratio	Molecules
EIF2 signaling	22.5	0.1830	RPL18, RPL14, RPLP0, RPL7, Rpl7a, RPL41, RPS4X, RPS12, RPL22L1, RPL31, RPS26, RPS13, RPL15, RPS16, RPS7, RPS19, RPS6, RPS15A, RPL11, RPS2, RPS5, RPL26, RPS18, RPL34, RPSA, RPL13, Gm11425, RPS9, RPS3, RPS23, RPL23A, RPL27A, RPS8, RPL18A, RPS11, RPL3, RPLP2
Regulation of eIF4 and p70S6K Signaling	7.57	0.1150	RPS18, RPS12, RPS4X, RPS26, RPS13, RPSA, RPS3, RPS16, RPS9, RPS7, RPS23, PPP2CA, RPS19, RPS6, RPS8, ITGB1, RPS15A, RPS11, RPS2, RPS5
mTOR Signaling	6.49	0.1000	RND3, RPS18, RPS12, RPS4X, HMOX1, RPS26, RPS13, RPSA, RPS3, RPS16, RPS9, RPS7, RPS23, PPP2CA, RPS19, RPS6, RPS8, RPS15A, RPS11, RPS2, RPS5
Nrf2-mediated oxidative stress response	3.85	0.0890	GPX2, GSTM5, ACTG1, AKR1A1, GCLC, HSPB8, GSTP1, GSTA1, HMOX1, GSTM1, FTL, JUN, EPHX1, NFE2L2, AKR7A3, ACTB, NQO1
Metabolism of xenobiotics by cytochrome P450	3.84	0.0612	GSTM5, GSTM1, Gstt3, CYP2B6, AKR1A1, UGT2B15, Cyp2c40, CYP1A2, GSTP1, GSTA1, AKR1C3, UGT2B4
Glutathione metabolism	2.88	0.0899	GPX2, GSTM5, GSTM1, Gstt3, GCLC, PRDX6, GSTP1, GSTA1
Arachidonic acid metabolism	2.09	0.0485	GPX2, LTC4S, CYP2B6, CYP4A22, PRDX6, PLA2G2A, Cyp2c40, PLA2G16, CYP1A2, AKR1C3
Acute phase response signaling	2.00	0.0734	APOA1, A2M, C4BPA, SERPINA3, RBP7, C4B, HMOX1, ORM1/ORM2, C4BPB, FTL, JUN, HP, HPX
B cell development	1.78	0.1210	HLA-DMA, HLA-DRB1, HLA-DRA, HLA-DMB
Aryl hydrocarbon receptor signaling	1.72	0.0692	HSPB1, GSTM5, GSTM1, MYC, RARB, JUN, NFE2L2, CYP1A2, GSTP1, NQO1, GSTA1
ERK/MAPK Signaling	1.56	0.0588	HSPB1, DUSP1, MYC, YWHAZ, PPP2CA, PRKAR2A, YWHAG, DUSP6, PLA2G2A, ITGB1, PPP1R3C, ETS1
Xenobiotic metabolism signaling	1.56	0.0508	GSTM5, CYP2B6, GCLC, UGT2B15, CYP1A2, GSTP1, GSTA1, HMOX1, GSTM1, FTL, PPP2CA, NFE2L2, FMO5, NQO1, UGT2B4
Eicosanoid signaling	1.56	0.0759	LTC4S, PTGER3, PRDX6, PLA2G2A, PLA2G16, AKR1C3
Complement system	1.56	0.1430	C4BPB, C6, C4BPA, C4B, C1QB
Pentose and glucuronate interconversions	1.56	0.0352	AKR1A1, UGT2B15, AKR7A3, AKR1C3, UGT2B4