Increased catabolism and decreased unsaturation of ganglioside in patients with inflammatory bowel disease

doi:10.3748/wjg.v21.i35.10080

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Sep 21, 2015; 21(35): 10080-10090
Published online Sep 21, 2015. doi: 10.3748/wjg.v21.i35.10080

Table 5 Unsaturated ceramide species of phosphatidylcholine in intestinal mucosa

Unsaturated Bonds	Control (BAP)(n = 6)	Control (CRC)(n = 12)	IBD(n = 11)	Pooled SEM
0	9.82	10.05	12.43	0.76
1	6.14	7.77	8.8	0.59
2	53.78	54.57	58.87	1.69
> 2	30.26^a	27.61^a	19.9^b	1.38
UI	2.33^a	2.27^b	2.06^b	0.03

Mean relative content of phosphatidylcholine (PC) stratified by the number of unsaturated bonds is presented. No significant differences were observed in species of PE. Superscript letters (a, b) denote differences (P < 0.05) among study groups. SEM: Standard error of the mean; CRC: Colorectal cancer; BAP: Benign adenomatous polyposis; UI: Unsaturation index; IBD: Inflammatory bowel disease.

Citation: Miklavcic JJ, Hart TD, Lees GM, Shoemaker GK, Schnabl KL, Larsen BM, Bathe OF, Thomson AB, Mazurak VC, Clandinin MT. Increased catabolism and decreased unsaturation of ganglioside in patients with inflammatory bowel disease. World J Gastroenterol 2015; 21(35): 10080-10090
URL: https://www.wjgnet.com/1007-9327/full/v21/i35/10080.htm
DOI: https://dx.doi.org/10.3748/wjg.v21.i35.10080