Increased catabolism and decreased unsaturation of ganglioside in patients with inflammatory bowel disease

doi:10.3748/wjg.v21.i35.10080

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Sep 21, 2015; 21(35): 10080-10090
Published online Sep 21, 2015. doi: 10.3748/wjg.v21.i35.10080

Table 3 Relative content of unsaturated bonds in GM3, GD3 and GD1a gangliosides in intestinal mucosa

	Unsaturated Bonds	Control (BAP) (n = 6)	Control (CRC) (n = 12)	IBD(n = 11)	Pooled SEM
GM3	0	5.73^a	2.77^b	3.3^a,b	0.41
	1	69.96	73.40	68.34	1.30
	2	21.86	21.62	25.24	1.05
	3	2.45	2.22	3.10	0.21
	UI	1.21	1.23	1.28	0.07
GD3	0	9.28	6.18	5.91	1.18
	1	59.39^c	58.67^c	87.88^d	2.91
	2	28.28^c	32.98^c	6.21^d	2.45
	3	3.09^c	2.18^c	ND^d	0.30
	UI	1.25^c	1.31^c	1.00^d	0.17
GD1a	0	5.32^a,b	6.8^a	3.11^b	0.68
	1	64.95^c	59.26^c	89.93^d	3.05
	2	26.21^c	30.51^c	8.06^d	2.44
	3	3.55^c	3.43^c	ND^d	0.44
	UI	1.28^c	1.31^c	1.06^d	0.17

Major classes of gangliosides stratified by number of unsaturated bonds are reported as average relative percent of respective major ganglioside. Superscript letters (a, b) denote differences (P < 0.05) among study groups; Superscript letters (c, d) denote differences (P < 0.01) among study groups. ND: Not detected; SEM: Standard error of the mean; CRC: Colorectal cancer; BAP: Benign adenomatous polyposis; UI: Unsaturation index; IBD: Inflammatory bowel disease.

Citation: Miklavcic JJ, Hart TD, Lees GM, Shoemaker GK, Schnabl KL, Larsen BM, Bathe OF, Thomson AB, Mazurak VC, Clandinin MT. Increased catabolism and decreased unsaturation of ganglioside in patients with inflammatory bowel disease. World J Gastroenterol 2015; 21(35): 10080-10090
URL: https://www.wjgnet.com/1007-9327/full/v21/i35/10080.htm
DOI: https://dx.doi.org/10.3748/wjg.v21.i35.10080