Increased catabolism and decreased unsaturation of ganglioside in patients with inflammatory bowel disease

doi:10.3748/wjg.v21.i35.10080

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Sep 21, 2015 (publication date) through Aug 31, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Sep 21, 2015; 21(35): 10080-10090
Published online Sep 21, 2015. doi: 10.3748/wjg.v21.i35.10080

Table 1 Relative content of GM3, GD3 and GD1a gangliosides in intestinal mucosa

	Control (BAP)(n = 6)	Control (CRC)(n = 12)	IBD(n = 11)	PooledSEM
GM3	27.5^a	24.4^a	48.6^b	3.8
GD3	26.3	39.4	31.4	2.4
GD1a	38.0^c	31.7^c	11.6^d	2.6

Mean total GM3, GD3 and GD1a are reported as average relative percent of total ganglioside within subject groups. Ganglioside species constituting less than 8% of total ganglioside are not listed (GT1a, GM1, GT3). Superscript letters (c, d) denote differences (P < 0.01) among study groups; Superscript letters (a, b) denote differences (P < 0.05) among study groups. SEM: Standard error of the mean; CRC: Colorectal cancer; BAP: Benign adenomatous polyposis; IBD: Inflammatory bowel disease.

Citation: Miklavcic JJ, Hart TD, Lees GM, Shoemaker GK, Schnabl KL, Larsen BM, Bathe OF, Thomson AB, Mazurak VC, Clandinin MT. Increased catabolism and decreased unsaturation of ganglioside in patients with inflammatory bowel disease. World J Gastroenterol 2015; 21(35): 10080-10090
URL: https://www.wjgnet.com/1007-9327/full/v21/i35/10080.htm
DOI: https://dx.doi.org/10.3748/wjg.v21.i35.10080