Development of a rat model of D-galactosamine/lipopolysaccharide induced hepatorenal syndrome

Figure 2 Histopathology of the liver (HE, × 200). A: In the NS group, hepatocytes were arranged in chords; B: In the GalN/LPS group at 6 h, focal necrosis of hepatocytes was visible; C: In the GalN/LPS group at 12 h, massive hemorrhagic hepatic necrosis was visible; D: In the GalN/LPS group at 24 h, massive hemorrhagic hepatic necrosis was visible; E: In the GalN group at 12 h, focal necrosis of hepatocytes was visible; F: In the LPS group at 12 h, hepatocytes began to show necrosis, and incomplete necrosis was observed in some hepatocytes. D-GalN: D-galactosamine; LPS: Lipopolysaccharide; NS: Normalsaline.