Dexamethasone inhibits hypoxia-induced epithelial-mesenchymal transition in colon cancer

Figure 4 Effects of dexamethasone on wound healing of colon cancer cells in hypoxia. A and B: Wound healing assay in HCT116 (A) and HT29 (B) cells treated with DEX (100, 200 nmol/L) and/or DFO (100 μmol/L) for 24 h; C and D: Effect of DEX on migration of HCT116 (C) and HT29 cells (D) was plotted as a percentage of wound closure. DEX diminished the ability to recover wounds of HCT116 and HT29 cells under hypoxic conditions. The error bar represents the standard deviation. Magnification × 40. ^aP < 0.05, ^bP < 0.01, and ^cP < 0.001 vs DFO-only groups. DEX: Dexamethasone; DFO: Deferoxamine.