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Copyright ©The Author(s) 2015.
World J Gastroenterol. Sep 14, 2015; 21(34): 9853-9862
Published online Sep 14, 2015. doi: 10.3748/wjg.v21.i34.9853
Table 1 Circulating microRNAs as diagnostic and prognostic biomarkers for hepatocellular carcinoma
MicroRNAsDiagnosis/prognosisUp/downregulated in plasma/serumPlasma/serumRelevanceRef.
miR-12Yes/NoUpregulatedSerumCompared with healthy control[67]
miR-122Yes/NoUpregulatedSerum[67]
miR-223Yes/NoUpregulatedSerum[67]
miR-122Yes/NoUpregulatedSerumCompared with healthy control[68]
miR-21Yes/NoUpregulatedPlasmaCompared with chronic hepatitis or healthy control[69]
miR-143Yes/NoUpregulatedSerumCompared with healthy control[6]
miR-215Yes/NoUpregulatedSerum[6]
miR-10bYes/NoUpregulatedSerumCompared with CLD or healthy control[74]
miR-106bYes/NoUpregulatedSerum[74]
miR-181aYes/NoDownregulatedSerum[74]
miR-206Yes/NoUpregulatedSerumHBV-related HCC compared with cirrhosis or healthy control[12]
miR-141-3pYes/NoUpregulatedSerum[12]
miR-433-3pYes/NoUpregulatedSerum[12]
miR-1228-5pYes/NoUpregulatedSerum[12]
miR-199a-5pYes/NoDownregulatedSerum[12]
miR-122-5pYes/NoDownregulatedSerum[12]
miR-192-5pYes/NoDownregulatedSerum[12]
miR-26a-5pYes/NoDownregulatedSerum[12]
miR-122Yes/NoDownregulatedPlasmaHBV-related HCC compared with chronic hepatitis B or healthy control[75]
miR-192Yes/NoUpregulatedPlasma[75]
miR-21Yes/NoUpregulatedPlasma[75]
miR-223Yes/NoDownregulatedPlasma[75]
miR-26aYes/NoDownregulatedPlasma[75]
miR-27aYes/NoDownregulatedPlasma[75]
miR-801Yes/NoUpregulatedPlasma[75]
miR-16Yes/NoDownregulatedSerumCompared with CLD or healthy control[78]
miR-21Yes/NoUpregulatedPlasmaCompared with chronic hepatitis or healthy volunteers[69]
miR-375dYes/NoDownregulatedSerumCompared with healthy control[87]
miR-199a-3pYes/NoDownregulated[87]
miR-30c-5pYes/NoUpregulatedSerumHCV-related HCC compared with healthy control[15]
miR-223-3pYes/NoDownregulatedSerum[15]
miR-302c-3pYes/NoUpregulatedSerum[15]
miR-17-5pYes/NoUpregulatedSerum[15]
miR-122No/YesUpregulatedSerumImproved overall survival[4]
miR-1No/YesUpregulatedSerumImproved overall survival[79]
miR-221No/YesUpregulatedSerumHigh serum miR-221 levels decreased survival rate[81]