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©The Author(s) 2015.
World J Gastroenterol. Sep 14, 2015; 21(34): 9838-9852
Published online Sep 14, 2015. doi: 10.3748/wjg.v21.i34.9838
Published online Sep 14, 2015. doi: 10.3748/wjg.v21.i34.9838
Table 4 Dysregulated microRNAs in hepatocellular carcinoma
| Symbol (location) | Materials | Detection methods | Pt | Survival | Relevant clinical factors | Functional analyses | Interacting molecules | In vivo study | Ref. |
| Early detection | |||||||||
| miR-21 (17q23.1) | Circulating | QPCR | 103 | - | Size, depth | - | - | - | [116] |
| miR-22 (17p13.3) | Tissue | QPCR | 32 | - | - | Proliferation, migration, invasion | CD151 | - | [117] |
| miR-29c (1q32.2) | Tissue | QPCR | 274 | - | - | Proliferation, adhesion, invasion, migration | ITGB1 | Yes | [135] |
| miR-30b (8q24.22) | Tissue | QPCR | 21 | - | - | Apoptosis | PAI-1 | Yes | [134] |
| miR-106b (7q22.1) | Circulating | QPCR | 40 | - | Age | - | - | - | [132] |
| miR-129 (7q32.1) | Gastric juice | QPCR | 141 | - | - | - | - | - | [118] |
| miR-141 (12p13.31) | Tissue | QPCR | 30 | - | - | Proliferation, migration, invasion | HDGF | - | [119] |
| miR-148a (7p15.2) | Tissue | QPCR | 64 | - | Size | - | - | - | [127] |
| miR-181c (19p13.13) | Tissue, circulating | QPCR | 30 | - | - | - | - | - | [113] |
| miR-191 (3p21.31) | Tissue, circulating | QPCR | 75 | - | T, stage | Proliferation, migration, invasion, cell cycle | - | - | [126] |
| miR-199a-3p (12) | Tissue, circulating | QPCR | 180 | - | T, N, stage | - | - | - | [115] |
| miR-223 (Xq12) | Circulating | QPCR | 60 | - | Helicobacter pylori | - | - | - | [109] |
| miR-233 (X) | Circulating | QPCR | 50 | - | Size, differentiation, stage | - | - | - | [130] |
| Monitoring recurrences | |||||||||
| miR-26a (3p22.2) | Tissue | QPCR | 40 | OS, RFS | N, stage | Proliferation, metastasis | FGF9 | Yes | [114] |
| miR-34b/c (11q23.1) | Noncancerous tissue | Pyrosequencing | 129 | RFS | Age | - | - | - | [128] |
| miR-185 (22q11.21) | Tissue | QPCR | 126 | OS, RFS | N, stage | Proliferation, metastasis | - | Yes | [129] |
| miR-196a (17q21.32) | Tissue, circulating | QPCR | 72 | - | - | Migration, invasion | - | - | [110] |
| miR-200c (12p13.31) | Circulating | QPCR | 52 | OS, PFS | - | - | - | - | [111] |
| miR-222 (Xp11.3) | Circulating | QPCR | 114 | OS, RFS | N, stage | - | - | - | [121] |
| Prediction of survival | |||||||||
| miR-25 (7q22.1) | Tissue, circulating | QPCR | 70 | OS | N, stage | Proliferation, migration, invasion | TOB1 | Yes | [124] |
| miR-132 (17p13.3) | Tissue | QPCR | 79 | OS | Lymphovascular invasion, N, stage | - | - | - | [125] |
| miR-183 (7q32.2) | Tissue | QPCR | 80 | - | Depth, N, stage | Proliferation, migration, invasion, apoptosis | PDCD4 | - | [122] |
| miR-192 (11q13.1) | Tissue | QPCR | 38 | - | Sex, vascular invasion, N | Invasion | - | - | [136] |
| miR-214 (1q24.3) | Tissue | QPCR | 80 | - | Size, N | Proliferation, migration, invasion | CSF1 | - | [131] |
| miR-630 (15q24.1) | Tissue | QPCR | 236 | OS | Depth, N, stage | - | - | - | [120] |
| Prediction of treatment response | |||||||||
| miR-17-5p (13q31.3) | Circulating | QPCR | 65 | OS | Differentiation, stage | - | - | - | [112] |
| miR-27a (19p13.13) | Circulating | QPCR | 82 | OS | Chemoresistance | - | - | - | [123] |
- Citation: Kanda M, Kodera Y. Recent advances in the molecular diagnostics of gastric cancer. World J Gastroenterol 2015; 21(34): 9838-9852
- URL: https://www.wjgnet.com/1007-9327/full/v21/i34/9838.htm
- DOI: https://dx.doi.org/10.3748/wjg.v21.i34.9838