CTLA-4 and MDR1 polymorphisms increase the risk for ulcerative colitis: A meta-analysis

Table 1 Baseline characteristics of all eligible studies

First author	Year	Ethnicity	Genotype method	Number		Gender (M/F)		Gene	SNP
				UC	Control	UC	Control
Brinar et al[29]	2013	Caucasian	PCR-RFLP	52/57		29.9 (26.0-35.70)	-	MDR1	C3435T
Repnik et al[35]	2010	Caucasian	PCR-RFLP	-	119/147	-	37.2	CTLA4	rs3087243 G/A
Ben Alaya et al[17]	2009	Africa	PCR-RFLP	18/47	52/48	39.9 (25-74)	32.4 (24-55)	CTLA4	rs231775 G/A
Farnood et al[30]	2007	Asian	PCR-RFLP	-	-	-	-	MDR1	C3435T
Magyari et al[19]	2007	Caucasian	PCR-RFLP	63/87	49/121	46.1 ± 1.3	57.7 ± 1.3	CTLA4	rs231775 G/A
Lankarani et al[32]	2006	Asian	PCR-RFLP	48/52	48/52	31.6 ± 13.4	35.36 ± 11.94	CTLA4	rs231775 G/A
Wang et al[37]	2006	Asian	PCR-RFLP	41/38	92/72	44.2 ± 16.2	37.8 ± 14.1	CTLA4	rs3087243 G/A
Osuga et al[34]	2006	Asian	PCR-RFLP	37/29	97/76	42.7 ± 14.2	19-76	MDR1	C3435T
Ho et al[31]	2006	Caucasian	PCR-RFLP	-	-	-	-	MDR1	C3435T
Rueda et al[20]	2005	Caucasian	TaqMan	-	-	-	-	CTLA4	rs3087243 G/A
Machida et al[33]	2005	Asian	PCR-RFLP	57/51	125/75	44.0 ± 16.9	32.5 ± 11.1	CTLA4	rs3087243 G/A
Machida et al[33]	2005	Asian	PCR-RFLP	57/51	125/75	44.0 ± 16.9	32.5 ± 11.1	CTLA4	rs231775 G/A
Schwab et al[36]	2003	Caucasian	TaqMan	86/63	86/63	34 ± 11	-	MDR4	C3435T

PB: Population-based; HB: Hospital-based; PCR-RFLP: Polymerase chain reaction restriction fragment length polymorphism; UC: Ulcerative colitis; MDR1: Multi-drug resistance 1; CTLA4: Cytotoxic T lymphocyte-associated antigen-4; SNP: Single nucleotide polymorphisms.