Notch1 downregulation combined with interleukin-24 inhibits invasion and migration of hepatocellular carcinoma cells

Figure 1 γ-secretase inhibitor-I/interleukin-24 combined treatment induces apoptotic cell death in hepatocellular carcinoma cells. A: Cytotoxic effects exerted on SMMC7721 cells by γ-secretase inhibitor-I (GSI-I) employed alone or in combination with recombinant interleukin (IL)-24. After treatment for 24 h cell viability was evaluated by MTT assay as reported in Materials and Methods; B: Cytotoxic effects exerted on HepG2 cells by GSI-I employed alone or in combination with recombinant IL-24. After treatment for 24 h cell viability was evaluated by MTT assay as reported in Materials and Methods. The data represent mean ± SD; ^aP < 0.05 vs control cells.