Value of screening endoscopy in evaluation of esophageal, gastric and colon cancers

Table 1 Accuracy of endoscopic modalities in esophageal carcinoma, which reveal the efficacy of endoscopic screening

Type of study	BE/ESCC	Patient group	Disease prevalence (%)	Accuracy of screen (%)
Endoscopic screening
Prospective	ESCC	Asymptomatic; Linxian, China	ESCC: 9.5	Relative risk of ESCC: 2.9/9.8/28.3 (mild/moderate/sever dysplasia); 34.4 (carcinoma in situ)
Prospective	ESCC	Asymptomatic; Linxian, China	Not determined	Sensitivity/specificity for high-grade dysplasia or ESCC: 62/79 (visible lesions); 96/63 (unstained lesions)
Ultrathin endoscopes
Randomized crossover	BE	GERD; United States	Not determined	Sensitivity: 26/30 (standard/small caliber endoscopy)
Randomized crossover	BE	BE and controls; United Kingdom	Not determined	Sensitivity/specificity small vs standard caliber: 100/100
Capsule endoscopy
Prospective single screen	BE	GERD and under surveillance BE; United States	Not determined	Sensitivity/specificity for BE: 67/84
Prospective single screen	BE	GERD; United States	Not determined	Sensitivity/specificity for BE: 60/100
Prospective single screen	BE	GERD; United States	Not determined	Sensitivity/specificity for BE: 78/82 (visual lesions); 93/78 (biopsy)

Adapted from Lao-Sirieix et al[11]. BE: Barrett’s esophagus; ESCC: Esophageal squamous cell cancer; GERD: Gastro-esophageal reflux disease.