Carvedilol may attenuate liver cirrhosis by inhibiting angiogenesis through the VEGF-Src-ERK signaling pathway

Figure 6 Effect of carvedilol on vascular endothelial growth factor angiogenic signaling. HUVECs were treated with VEGF (50 ng/mL) for 2 h in the presence or absence of different concentrations of carvedilol. Cell lysates were processed as indicated in the Materials and Methods. p-VEGFR2/VEGFR2 (A) and p-ERK/ERK (B) levels (n = 3, ^aP < 0.05 vs control, ^cP < 0.05, ^bP < 0.01 vs VEGF alone). ERK: Extracellular signal-regulated kinase.