Carvedilol may attenuate liver cirrhosis by inhibiting angiogenesis through the VEGF-Src-ERK signaling pathway

Figure 4 Effect of carvedilol on cell invasion. A: HUVECs were seeded in the upper chamber of a Transwell and treated with various concentrations of carvedilol. The bottom chamber was filled with VEGF-enriched media. After 12 h, the HUVECs that migrated through the membrane were stained by hematoxylin and eosin; B: Cell numbers were quantified (n = 12, ^aP < 0.05 vs control, ^cP < 0.05, ^bP < 0.01 vs VEGF alone).