Prognosis of acute-on-chronic liver failure patients treated with artificial liver support system

Table 2 Univariate and multivariate analyses of risk factors for survival

Variable	Univariate		Multivariate
	HR (95%CI)	P value	HR (95%CI)	P value	Coefficient
Age	1.045 (1.024-1.067)	< 0.001	1.031 (1.008-1.054)	0.008	0.030
Gender1	0.704 (0.296-1.676)	0.428
Etiology2	0.736 (0.178-3.049)	0.673
MELD score	1.120 (1.080-1.161)	< 0.001	1.102 (1.056-1.150)	< 0.001	0.097
Total bilirubin	1.002 (1.000-1.003)	0.047
ALT	1.001 (1.000-1.002)	0.022
AST	1.001 (1.000-1.002)	0.011
Creatinine	1.003 (1.000-1.005)	0.055
BUN	1.083 (1.015-1.157)	0.017
INR	1.369 (1.209-1.550)	< 0.001
Times3	0.753 (0.549-1.034)	0.080
Complication4	2.246 (1.721-2.933)	< 0.001	1.694 (1.224-2.344)	0.001	0.527
ALSS5	0.455 (0.242-0.856)	0.015	0.454 (0.232-0.889)	0.021	-0.790

¹Gender: 0 = male, 1 = female;

²Etiology: 0 = nonviral, 1 = viral;

³Times of ALSS: 1 = 1, 1 = 1, 2 = 2, 3 = 3, 4 = 4, 5 = 5, 6 = 6;

⁴Number of complications: 1 = 1, 2 = 2, 3 = 3, 4 = 4, 5 = 5;

⁵Type of ALSS: 0 = PE, 1 = PE plus PBA. MELD: Model for end-stage liver disease; AST: Aspartate aminotransferase; ALT: Alanine aminotransferase; INR: International normalized ratio; ALSS: Artificial liver support system.