Robotic radiosurgery in pancreatic cancer: A systematic review

Table 3 Results

Ref.	Tumor response criteria	Tumor response (%)	Median overall survival (mo)	Local control	Toxicity scale	Grade 3-4toxicity
Koong et al[17], 2004	-	NR	11.0	LP: 20%1	RTOG	0%
Koong et al[18], 2005	-	NR	7.7; 1-yr: 15%	LP: 6.2%2	RTOG	Acute: Gastroparesis:10.5%3
Schellenberg et al[19], 2008	-	NR	11.4; 1 yr: 50%	LP: 19%	CTC 3.0	Acute: gastric ulcer: 6.2%; Late: duodenal stenosis: 6.2%; Duodenal perforation: 6.2%4
Seo et al[20], 2009	RECIST	68 (PR: 68)	14.0; 1 yr: 60%	LP: 44% LPFS (1-yr): 70.2 %;	RTOG	Acute: duodenal obstruction: 3.3%; Late: 0%
Goyal et al[21], 2012	RECIST	44 (CR: 13, PR: 31)	14.45; 1 yr: 56%	LPFS (1-yr): 65% LPFS (median): 11.4 mo	CTC 3.0	GI ulcer: 16%6

¹Local progressions: 0% in patients receiving 25 Gy;

²In patients receiving RRS;

³Unreported rate of late duodenal ulcers;

⁴Five duodenal ulcers were classified G2;

⁵14.8 mo in M0 patients;

⁶Asymptomatic pyloric ulcer: 5.7%. CR: Complete response; GI: Gastrointestinal; LP: Local progression; LPFS: Local progression free survival; NR: Not reported; PR: Partial response.