Protective effect of Salvia miltiorrhiza and Carthamus tinctorius extract against lipopolysaccharide-induced liver injury

Figure 8 Pharmacological mechanism of Danhong injection on lipopolysaccharide-induced acute liver injury. Danhong injection (DHI) protected against lipopolysaccharide (LPS)-induced acute liver injury by regulating IκBα, and nuclear factor (NF)-κB p65 phosphorylation as well as NF-κB p65 translocation from the cytoplasm to the nucleus. Subsequently, TNF-α and IL-6 secretion, Bax and Bcl-2 expression, and caspase-3 activity were modified and balanced.