Epigenetic regulation of DNA repair machinery in Helicobacter pylori-induced gastric carcinogenesis

Figure 1 Proposed mechanism by which Helicobacter pylori induced epigenetic alteration affecting DNA repair. The more virulent Helicobacter pylori strains (cagA and vacA s1m1) increase the inflammatory response, 8-oxodG and ROS production on epithelial cells. This landscape may cause the hypermethylation of CpG islands and/or the histone hypoacetylation, which results the in the DNA repair gene silencing. It might increase the mutation rate which may contribute to the genomic instability and gastric cancer development.